Trospium chloride
Cobenfy, Trospium (trospium chloride) is a small molecule pharmaceutical. Trospium chloride was first approved as Sanctura on 2004-05-28. It is used to treat overactive urinary bladder and urge urinary incontinence in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Trospium
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cobenfy | New Drug Application | 2024-09-30 |
| trospium chloride | ANDA | 2025-02-13 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| overactive urinary bladder | EFO_1000781 | D053201 | N32.81 |
| urge urinary incontinence | EFO_0006865 | D053202 | N39.41 |
Agency Specific
FDA
EMA
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HCPCS
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Clinical
Clinical Trials
55 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 3 | — | 1 | 7 | 6 | 17 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 2 | 1 | 8 | 2 | — | 13 |
| Urinary incontinence | D014549 | — | R32 | 2 | — | 1 | 4 | — | 7 |
| Enuresis | D004775 | — | R32 | 2 | — | 1 | 3 | — | 6 |
| Urge urinary incontinence | D053202 | EFO_0006865 | N39.41 | — | — | 1 | 1 | — | 2 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | 1 | — | — | 1 | — | 2 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | 1 | — | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | 1 | — | 1 |
| Cognition | D003071 | EFO_0003925 | — | — | — | — | 1 | — | 1 |
| Mental competency | D016743 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | 7 | — | — | 7 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 1 | — | 4 | — | — | 5 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | 4 | — | — | 4 |
| Mania | D000087122 | — | F30 | — | — | 3 | — | — | 3 |
| Cystitis | D003556 | EFO_1000025 | N30 | 1 | — | 1 | — | — | 2 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | 2 | — | — | 2 |
| Interstitial cystitis | D018856 | EFO_1000869 | N30.1 | — | — | 1 | — | — | 1 |
| Pelvic pain | D017699 | — | — | — | — | 1 | — | — | 1 |
| Psychomotor agitation | D011595 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | 2 | — | — | — | 2 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | 2 | — | — | — | 2 |
| Obstructive lung diseases | D008173 | — | — | 1 | 2 | — | — | — | 2 |
| Respiratory aspiration | D053120 | EFO_1001839 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Accidental injuries | D000081084 | — | — | 1 | — | — | — | — | 1 |
| Problem behavior | D000066553 | — | — | 1 | — | — | — | — | 1 |
| Radiation injuries | D011832 | — | T66 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urologic diseases | D014570 | — | N39.9 | — | — | — | — | 1 | 1 |
| Urinary bladder diseases | D001745 | — | N32.9 | — | — | — | — | 1 | 1 |
| Ureterolithiasis | D053039 | EFO_1001228 | N20.1 | — | — | — | — | 1 | 1 |
| Ureteral obstruction | D014517 | — | — | — | — | — | — | 1 | 1 |
| Deprescriptions | D000069340 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Trospium chloride |
| INN | trospium chloride |
| Description | Trospium chloride is a muscarinic antagonist used to treat overactive bladder. It has side effects typical of this class of drugs, namely dry mouth, stomach upset, and constipation; these side effects cause problems with people taking their medicine as directed. However it doesn't cause central nervous system side effects like some other muscarinic antagonists. It is in pregnancy category C and is excreted in breast milk.
|
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1.[Cl-] |
Identifiers
| PDB | — |
| CAS-ID | 10405-02-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3084748 |
| ChEBI ID | — |
| PubChem CID | 107979 |
| DrugBank | DBSALT000883 |
| UNII ID | 1E6682427E (ChemIDplus, GSRS) |
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Cobenfy – Bristol Myers Squibb
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Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 534 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,193 adverse events reported
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